A bioreducible linear poly(β-amino ester) for siRNA delivery.
نویسندگان
چکیده
Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.
منابع مشابه
Bioreducible Cationic Polymer-Based Nanoparticles for Efficient and Environmentally Triggered Cytoplasmic siRNA Delivery to Primary Human Brain Cancer Cells
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عنوان ژورنال:
- Chemical communications
دوره 49 46 شماره
صفحات -
تاریخ انتشار 2013